Genes can predict baldness in men
Many of these genes, they explain, are associated with hair structure and development - which is likely why they are associated with hair loss - while other genes associated with more hair loss were linked to shorter stature, fewer offspring, and a lower risk of bipolar disorder. The scientists said they would expect to see even stronger genetic associations with hair loss if they were able to include information about which men experienced early onset hair loss. Using data from 53,000 men in the United Kingdom, they've come up with a DNA-based algorithm that could someday predict whether one is likely to go bald-one that's more reliable than family history. These new findings could be used to predict the chances that a man will suffer from severe hair loss.
It is thought to be caused by oversensitive hair follicles, linked to having too much of a certain male hormone.
Male pattern baldness affects 30 percent of men under 30 and 80 percent of men by the time they're 80 years old. More accurate predictions are still undergoing experimentation to be able to help identify sub-groups of the population that have a higher risk of losing their hair.
Hair loss also occurs after major surgery or childbirth, for example.
"We identified over two hundred independent, novel genetic correlates of male pattern baldness, an order of magnitude greater than the list of previous genome-wide hits", lead researchers Saskia Hagenaars and David Hill, concluded.
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"We are still a long way from making an accurate prediction for an individual's hair loss pattern", principal study investigator Riccardo Marioni, of the University of Edinburgh, said in a statement from the Public Library of Science posted on Medical Xpress. They were all part of the huge British genetic experiment called the BioBank. Of the men included in the study, 16,700 showed no hair loss, 12,000 slight lost hair, 14,000 showed moderate hair loss while 9,800 displayed severe hair loss.
Scottish scientists out of the University of Edinburgh say that they've narrowed down more than 200 genetic regions tied to male baldness. This will be based on the presence or absence of genetic markers present in men. The findings could provide possible targets for drug development to treat baldness, according to the researchers.
"It was interesting to find that numerous genetic signals for male pattern baldness came from the X chromosome, which men inherit from their mothers".
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Feb 16 2017