Fresh Messi leads Barca blowout of Sevilla
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Leganes may also make changes if coach Asier Garitano decides to target the weekend trip to play bottom of the table Osasuna, rather than look for a miracle against the league leaders; something which will of course only make Madrid's job on Wednesday that bit easier.
Sevilla may not be in the title race in La Liga right now, but they have an opportunity to play spoiler in that race, with a match against Barcelona at the Camp Nou on the cards.
However, since then Sevilla have been knocked out of the Champions League by Leicester City and tumbled out of contention for the La Liga title with Atletico Madrid passing them into third place.
This time a loose ball inside the penalty area is emphatically buried by Messi on the full volley.
Sampaoli's chances of replacing Luis Enrique, who will leave when his Barcelona contract expires in June, have dwindled, with Athletic Bilbao's Ernesto Valverde and current assistant coach Juan Carlos Unzue now the favorites. The Andalusians have really hit a awful run of form and come into this game without a win in 5 matches, having failed to see off lowly Sporting Gijon at home at the weekend.
Ter Stegen made a comfortable stop from second-half substitute Pablo Sarabia before the same player hit the side netting with an effort from wide right.
Messi, who has now scored 43 goals in 41 matches for Barcelona this season, was playing his first game in almost two weeks.
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Madrid will have to do without Cristiano Ronaldo and Gareth Bale after they were rested by Zidane.
Madrid has won four in a row in the league and has scored at least a goal in its last 50 games in all competitions.
Luis Suarez was replaced for the final 25 minutes as Enrique took the chance to rest the Uruguay global, but there was still plenty happening at Camp Nou, with Sarabia again testing Ter Stegen from distance, and Iniesta missing the chance to make it 4-0 after being found by Messi inside the Sevilla box.
"We got the three points, which is what matters", Madrid defender Nacho Fernandez said.
What time does the Barcelona vs Sevilla match start at?
Elsewhere, Real Madrid beat Alaves 3-0.
Second-to-last-place Granada drew 0-0 with Deportivo in La Coruna, while Sporting Gijon, also in the relegation zone, lost 1-0 at home to Malaga.
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